The incident occurred at Hillingdon Street, Kennington, just after 9.15 pm yesterday (April 14).
The officers and teams of the London ambulance service attended and found a man who had been stabbed.
He was declared dead shortly after.
Police consultations are ongoing to locate their relatives.
We have contacted the London ambulance service for more information.
A Metropolitan Police spokesman said: “On Monday, April 14 at 9.16 pm, the police were called to Hillingdon Street, Camberwell, after reports of a stabbing.
“The officers attended the scene along with the London ambulance service that treated a 21 -year -old man for weapon wounds.
“Unfortunately, despite his best efforts, he was declared dead on the scene. The consultations are ongoing and we are working to locate their closest.
“If you saw something or have any information, contact the policy through 101 indicated by CAD7392/14apr.
“Alternatively, to remain in anonymity you can call Crimeppers at 0800 555 111”.